Omega-3 Fatty Acids (EPA/DHA)
fatty acid
Effective Dose Range (dog)
Min Effective
50 mg/kg body weight combined EPA+DHA
Optimal Low
75 mg/kg body weight combined EPA+DHA
Optimal High
150 mg/kg body weight combined EPA+DHA
Upper Limit
300 mg/kg body weight combined EPA+DHA
Research Evidence
Evidence GradeGrade A — Strong
PubMed Studies63
Safety Data
FDA Adverse Events5
Generally safe. High doses may affect platelet function. Source quality matters — ensure low heavy metal content. Store properly to prevent oxidation.
Mechanism of Action
Compete with arachidonic acid to reduce pro-inflammatory eicosanoid production. Incorporate into cell membranes improving skin barrier function. Support sebaceous gland health.
Products Containing Omega-3 Fatty Acids (EPA/DHA)
Top-rated supplements featuring this ingredient, ranked by our PSI+ score.
Nutri-Vet Shed Defense Soft Chews for Dogs
Nutri-Vet
PSI+ 88.0$18.99
PetHonesty 10-in-1 Dog Multivitamin Chews - Senior Dog Vitamins with Glucosamine, Probiotics, Omegas, Vitamins & Minerals
PetHonesty
PSI+ 88.0$32.99
Pawfy 10-in-1 Multivitamin for Dogs - Immune, Joint, Skin, Gut & Heart Health
Pawfy
PSI+ 88.0$27.99
Purina Pro Plan Veterinary Diets Joint Supplement for Dogs, Hip & Joint Soft Chews for Large Dogs
Purina Pro Plan Veterinary Diets
PSI+ 86.0$19.99
PetHonesty Advanced Allergy & Immune Supplement for Dogs - Salmon
PetHonesty
PSI+ 84.0$26.99
Zesty Paws 8-in-1 Multivitamin for Senior Dogs - Glucosamine Chondroitin for Joint Health
Zesty Paws
PSI+ 78.0$29.97
Flexadin Advanced for Dogs
Vetoquinol
PSI+ 77.0$39.99
NaturVet Aller-911 Advanced Allergy Aid Plus Immune Support Soft Chews for Dogs, 60 Count
NaturVet
PSI+ 71.0$22.49